Biotechnology : Important Events And Discoveries In Biotechnology

Biotechnology is not a new advancement in the area of science. It actually has been utilized for years, but was not significantly described as biotechnology. In its simple form, biotechnology means utilizing living organisms or their products to revise or change human health or the environment, or to run a process. Biotechnology itself is the combination of biology and other sciences to create new, innovative products in the agricultural sector, industrial sector and environmental industries. The products include medicines, vaccines, growth hormones for plants and food additives. There are nine major areas of this technology and its applications in the field of biotechnology. These nine major areas are bioprocessing technology, monoclonal antibodies, cell culture, recombinant DNA technology, cloning, protein engineering, biosensors, nanobiotechnology and microarrays. Bioprocessing technology refers to use of living cells to produce preferred products. This method has been utilized for thousands of years without knowing the actual scientific implications of it, such as in beer brewing, winemaking and even for making bread and pickles! Microorganisms were first discovered in the mid-1800s, and people came to realize that their biochemical machinery was the substance for these useful products. In-depth research and further experiments have led us today to the production of amino acids, birth control pills, pesticides, antibiotics and also vitamins, just to name a few. Monoclonal antibody technology uses the cells from the immune system to make antibodies. Monoclonal antibodies are extremely useful to locate any pollutants found in the environment, detect microorganisms that may be harmful in food, differentiate between normal cells and cancer cells, and also diagnose in a more precise manner any infectious diseases that may be present in humans, animals or plants. Cell culture simply means growing cells outside of a living organism. There are 3 areas in this study, which include plant cell culture, insect cell culture and mammalian cell culture. Recombinant DNA technology, in the plain sense of the word, means recombining 2 pieces of DNA from 2 different species. This is used to produce new medicines and vaccines, slow down the process of food spoilage, control viral diseases and hamper inflammation, just to name a few. Cloning became well-known after the cloning of Dolly the sheep years back. Cloning technology actually allows for the generation of genetically identical molecules, plants, cells or animals. Protein engineering is a DNA recombinant technique that is meant to improve existing proteins to create new proteins that do not exist in nature. These proteins may then be used in food processing, drug development and industrial manufacturing. Biosensors are a combination of biology and the advances in microelectronics. Biosensors are detecting devices that rely on the specificity of cells and molecules to identify and measure substances at extremely low concentrations, which is why they are highly used to measure the nutritional value, safety and freshness of food, detect explosives, toxins and bio-warfare agents, locate and measure pollutants, and also to provide emergency room physicians with bedside measurements of vital blood components. 

Nano-biotechnology refers to the study, manipulation and manufacture of ultra-small structures and machines that can consist of only  a single molecule.  This field of study enables us to improve the specificity and timing of drug delivery, increase the speed and power of diagnosing diseases, and also encourage the development of green manufacturing practices.  

Microarray is the study of gene structure and functions which enable us to analyze tens of thousands of samples simultaneously.  This field allows us to monitor gene activity, identify genes that are important to crop productivity, and also to detect mutations in disease-related genes

The Age of biotechnology arrives with “somatostatin” - a human growth hormone-releasing inhibitory factor, the first human protein manufactured in bacteria by Genentech, Inc. A synthetic, recombinant gene was used to clone a protein for the first time.

1978:

Genentech, Inc. and The City of Hope National Medical Center announce the successful laboratory production of human insulin using recombinant DNA technology. Hutchinson and Edgell show it is possible to int

The Age of biotechnology arrives with “somatostatin”  a human growth hormone releasing inhibitory factor, the first human protein manufactured in bacteria by Genentech, Inc. A synthetic, recombinant gene was used to clone a protein for the first time.

1979:

Sir Walter Bodmer suggests a way of using DNA technology to find gene markers to show up specific genetic diseases and their carriers. John Baxter reports cloning the gene for human growth hormone.

1980:

The prokaryote model, E. coli, is used to produce insulin and other medicine, in human form. Researchers successfully introduce a human gene - one that codes for the protein interferon into a bacterium. The U.S. patent for gene cloning is awarded to Cohen and Boyer.

1981:

Scientists at Ohio University produce the first transgenic animals by transferring genes from other animals into mice. The first gene synthesizing machines are developed. Chinese scientists successfully clone a golden carp fish.

1982:

Genentech, Inc. receives approval from the Food and Drug Administration to market genetically engineered human insulin. Applied Biosystems, Inc. introduces the first commercial gas phase protein sequencer.

1983:

The polymerase chain reaction is invented by Kary B Mullis. The first artificial chromosome is synthesized, and the first genetic markers for specific inherited diseases are found.

1984:

Chiron Corp. announces the first cloning and sequencing of the entire human immunodeficiency virus (HIV) genome. Alec Jeffreys introduces technique for DNA fingerprinting to identify individuals. The first genetically engineered vaccine is developed.

1985:

Cetus Corporation's develops GeneAmp polymerase chain reaction (PCR) technology, which could generate billions of copies of a targeted gene sequence in only hours. Scientists find a gene marker for cystic fibrosis on chromosome number 7.

1986:

The first genetically engineered human vaccine  Chiron's Recombivax HB  is approved for the prevention of hepatitis B. A regiment of scientists and technicians at Caltech and Applied Biosystems, Inc. invented the automated DNA fluorescence sequencer.

1987:

The first outdoor tests on a genetically engineered bacterium are allowed. It inhibits frost formation on plants. Genentech's tissue plasminogen activator (tPA), sold as Activase, is approved as a treatment for heart attacks.

1988:

Harvard molecular geneticists Philip Leder and Timothy Stewart awarded the first patent for a genetically altered animal, a mouse that is highly susceptible to breast cancer

1989:

UC Davis scientists develop a recombinant vaccine against the deadly rinderpest virus. The human genome project is set up, a collaboration between scientists from countries around the world to work out the whole of the human genetic code.

1990:

The first gene therapy takes place, on a four year old girl with an immune-system disorder called ADA deficiency. The human genome project is formally launched.

1991:

Mary-Claire King, of the University of California, Berkeley, finds evidence that a gene on chromosome 17 causes the inherited form of breast cancer and also increases the risk of ovarian cancer. Tracey the first transgenic sheep is born.

1992:

The first liver xenotransplant from one type of animal to another is carried out successfully. Chiron's Proleukin is approved for the treatment of renal cell cancer.

1993:

The FDA declares that genetically engineered foods are "not inherently dangerous" and do not require special regulation. Chiron's Betaseron is approved as the first treatment for multiple sclerosis in 20 years.

1994:

The first genetically engineered food product, the Flavr Savr tomato, gained FDA approval. The first breast cancer gene is discovered. Genentech's Nutropin is approved for the treatment of growth hormone deficiency.

1995:

Researchers at Duke University Medical Center transplanted hearts from genetically altered pigs into baboons, proving that cross-species operations are possible. The bacterium Haemophilus influenzae is the first living organism in the world to have its entire genome sequenced.

1996:

Biogen's Avonex is approved for the treatment of multiple sclerosis. The discovery of a gene associated with Parkinson's disease provides an important new avenue of research into the cause and potential treatment of the debilitating neurological ailment.

1997:

Researchers at Scotland's Roslin Institute report that they have cloned a sheep named Dolly from the cell of an adult ewe. The FDA approves Rituxan, the first antibody-based therapy for cancer.

1998:

The first complete animal genome the C.elegans worm is sequenced. James Thomson at Wisconsin and John Gearhart in Baltimore each develop a technique for culturing embryonic stem cells.

1999:

A new medical diagnostic test will for the first time allow quick identification of BSE/CJD a rare but devastating form of neurologic disease transmitted from cattle to humans. 

2000:

"Golden Rice," modified to make vitamin A. Cloned pigs are born for the first time in work done by Alan Coleman and his team at PPL, the Edinburgh-based company responsible for Dolly the sheep.

2001:

The sequence of the human genome is published in Science and Nature, making it possible for researchers all over the world to begin developing genetically based treatments for disease.

2002:

Researchers sequence the DNA of rice, and is the first crop to have its genome decoded.

2003:

The sequencing of the human genome is completed.